Our
program

KCNT1-related epilepsy is a rare and often fatal pediatric developmental epileptic encephalopathy with a U.S. prevalence that Actio estimates to be 2,500 patients. KCNT1-related epilepsy patients typically have a normal prenatal course before developing sporadic, asynchronous focal seizures. Seizure onset is often in the first six months of life, and the median age of onset is approximately 3.5 weeks. Seizure frequency tends to increase over time and can reach up to 50 seizures per day (15-20 per day on average). Other common symptoms and complications of KCNT1-related epilepsy include developmental delays and profound cognitive impairments and neurological deficits. There are currently no approved therapies for KCNT1-related epilepsy.